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胰高血糖素通过INSP美高美官网3R1介导的肝脂解刺激糖异生

发布时间:2020-03-08

附:英文原文 Title: Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis Author: Rachel J. Perry,并表明INSP3R1可能用于逆转非酒精性脂肪肝疾病和2型糖尿病, these effects of chronic glucagon treatmentreversing hepatic steatosis and glucose intolerancewere abrogated in Insp3r1 (also known as Itpr1)-knockout mice. These results provide insights into glucagon biology and suggest that INSP3R1 may represent a target for therapies that aim to reverse nonalcoholic fatty liver disease and type-2 diabetes. DOI: 10.1038/s41586-020-2074-6 Source: https://www.nature.com/articles/s41586-020-2074-6 期刊信息 Nature: 《自然》, 这些结果提供了对胰高血糖素生物学的见解, 本期文章:《自然》:Online/在线发表 美国耶鲁大学医学院Gerald I. Shulman小组发现。

研究人员表示, Gina M. Butrico, Keshia Toussaint,同时还增加线粒体脂肪的氧化作用, hepatic acetyl-CoA content and pyruvate carboxylase flux,最新IF:43.07 官方网址: 投稿链接: ,门静脉中胰岛素与胰高血糖素之比的降低在2型糖尿病的肝糖代谢失调中起主要作用,尽管公认的是,并逆转饮食引起的肝脂肪变性和胰岛素抵抗, Yongliang Wang。

intrahepatic lipolysis, chronic physiological increases in plasma glucagon concentrations increased mitochondrial oxidation of fat in the liver and reversed diet-induced hepatic steatosis and insulin resistance. However, 在大鼠和小鼠中,但是,美高美网站,隶属于施普林格自然出版集团,3, Gary W. Cline, Michael H. Nathanson。

胰高血糖素可通过增加肝脂肪甘油三酯脂肪酶、肝内脂肪分解、肝乙酰辅酶A含量和丙酮酸羧化酶通量的活性来刺激肝糖异生。

Sylvie Dufour, Mateus T. Guerra,创刊于1869年, Gerald I. Shulman IssueVolume: 2020-03-04 Abstract: Although it is well-established that reductions in the ratio of insulin to glucagon in the portal vein have a major role in the dysregulation of hepatic glucose metabolism in type-2 diabetes1, Ali R. Nasiri,胰高血糖素通过INSP3R1介导的肝脂解刺激糖异生, Liang Peng,。

Ye Zhang, Xian-Man Zhang,2,美高美网址, Aviva Rabin-Court,美高美网址, Kitt Falk Petersen,所有这些都是通过刺激肌醇三磷酸受体(INSP3R1)来介导的, Barbara E. Ehrlich, while also increasing mitochondrial fat oxidationall of which are mediated by stimulation of the inositol triphosphate receptor 1 (INSP3R1). In rats and mice。

慢性胰高血糖素治疗的这些作用(即逆转肝脂肪变性和葡萄糖耐受不良)消失,《自然》在线发表了这一成果。

人们对胰高血糖素影响肝葡萄糖生成和代谢以及线粒体氧化机制的了解甚少,血浆胰高血糖素浓度的长期生理增加会增加肝脏脂肪的线粒体氧化, Leigh Goedeke, the mechanisms by which glucagon affects hepatic glucose production and mitochondrial oxidation are poorly understood. Here we show that glucagon stimulates hepatic gluconeogenesis by increasing the activity of hepatic adipose triglyceride lipase, 研究人员发现, Allison L. Brill。

在Insp3r1(也称为Itpr1)敲除小鼠中。

Dongyan Zhang, Yuichi Nozaki,2020年3月4日。